Technology Overview

Ultradian’s firt product, Biologue, is a pain-free electrochemical biosensor that measures glucose within interstitial fluid, less invasively, just below the skin surface, in the dermis and transmits the data wirelessly to a hand-held monitor or smart phone. The disposable Biologue sensor consists of a small micro-needle coated with an enzyme that reacts specifically with glucose in the interstitial fluid to produce an electrical signal, directly proportional to glucose concentration.

Biologue incorporates methods to minimize biofouling, reduce lag time and remain stable for long periods without the need for frequent recalibration using a fingerstick blood glucose meter.  Biofouling is the body’s reaction to a foreign object, similar to how the body reacts to a sliver of wood. This reaction encapsulates the sensor in a fibrin sheath (scar tissue) thus reducing the amount of glucose reaching the active part of the sensor where measurements are made. This leads to inaccurate readings and the need for fingerstick recalibrations numerous times per day.

Our unique design of placing a sensor on the skin surface is a significant advance for two reasons:

Biologue’s small size, self-correction capability, and 100 times higher signal to noise versus competitive systems, are key advancements that increase accuracy and ease of use.

The Biologue continuous glucose monitor represents a breakthrough in terms of accuracy and simplicity. This is supported by independent third party data derived from human pilot studies at SUNY Upstate Medical University in Syracuse, NY that were funded by the National Institute of Diabetes, Digestive, and Kidney Disease (NIDDK),  

It is our belief that collectively these product characteristics position Ultradian’s Biologue at the forefront of pain-free, calibration-free, minimally invasive continuous glucose monitoring technology as a stand-alone replacement system for fingerstick testing. Additionally, Biologue's advanced features make it an ideal platform for integration with an insulin pump, creating a closed loop artificial pancreas.